This is a COM permissions problem.
- Start > Run > dcomcnfg (or “mmc -32” and then add the Component Services snap-in manually if you can’t find the app under step 3)
- Navigate to Component Services > Computers > My Computer > DCOM Config
- Locate the MS application giving you trouble (eg: “Microsoft Excel Application” for Excel or “Microsoft Word 97 – 2003 Document” for Word)
- Right click > Properties
- On the security tab: Select Customize under Launch and Activation Permissions / Access Permissions and click Edit…
- Add the account under which the site is running (eg: Network Service) and assign Local Launch & Local Activation permissions
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